A promising young doctor, Kirihito Osanai visits a remote Japanese mountain village to investigate the source of the latest medical mystery. While he ends up traveling the world to discover what it takes to be cured of such a disease, a conspiracy back home attempts to explain away his absence. Hinging upon his fate are those of his loved ones: an unstable childhood friend and colleague trapped between factions of the medical establishment that nurtured him; a fiancee emotionally transformed by Kirihito's mysterious disappearance; and a stranger who becomes his guardian angel, a sensual circus-act performer with volatile psychological secrets.