IS (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. IS stands for Inter Sexuality.

This manga deals with very serious issues concerning intersexual people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are - It's all there in a form of manga.

First volume has different cases but from volume two onwards manga becomes a longer tale of Hoshino Haru, IS and their life, trials and tribulations towards the adulthood.