The main character of the manga, a young man called Shizuku Kanzaki, discovers the beauty of wine after his father, a famous wine critic, dies and leaves an unusual will: a description of 12 wines he considers to be the best in the world, comparing them to Jesus Christ's disciples.

The first person to find these "disciples" will inherit the father's wine collection, a contest that pits Shizuku against his adoptive brother, Issey Tomine, who works as a wine critic.